Reviewed 12 popular weight loss drugs and supplements
There are many ways to lose weight to choose from.
Including various pills, medicines and natural supplements.
It is said that these products can help you lose weight or make it easier to lose weight when used in combination with other methods.
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They work through one or more of the following mechanisms:
Reduce appetite, make you feel fuller and consume fewer calories
The absorption rate of nutrients such as fat is low. Eat fewer calories
Increase fat burning, thereby burning more calories
These are the top 12 weight loss supplements and pills that are scientifically rated.
1. Garcinia Cambogia Extract
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Hold him down!
Garcinia cambogia was promoted globally due to the appearance of Dr. Oz in 2012.
It is small and green with a shape similar to a pumpkin.
Hydroxycitric acid (HCA) is found in the skin of this fruit. This active ingredient is found in Garcinia Cambogia extract and sold as a weight loss drug.
Effect: Animal studies have shown that it can inhibit fat-producing enzymes in the body and increase serotonin levels. This may help suppress cravings.
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Effectiveness: A study involving 130 people evaluated Garcinia Cambogia and dummies. There was no difference in weight or percentage between the two groups.
In 12 studies reviewed in 2011, an average weight loss of 2 pounds (or 0.88 kg) was found.
Side effects Although no serious side effects have been reported, some people have reported mild digestive problems.
Bottom line
Garcinia cambogia can cause moderate weight loss, but the effect is not so obvious that it is unlikely to be noticed.
2. Hydroxy Cleavage
Hydroxycut is a weight loss supplement that has been around for more than a decade. There are many kinds of Hydroxycut, but the most popular is "Hydroxycut".
What it does: It contains a variety of ingredients that can help you lose weight, such as caffeine and some plant extracts.
Effectiveness A 5 study found that it can lose 21 pounds (9.5 kg) in 3 months (5).
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Side effects: If you are sensitive to caffeine, you may feel anxious, nervous or trembling, nausea and diarrhea, and irritability.
Bottom line
There is only one study on this supplement and no long-term data. We need more research.
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3. Caffeine
Caffeine is the most widely consumed psychoactive substance in the world, yes.
It can be found in green tea and black cocoa.
Caffeine is a well-known metabolism booster and is usually included in commercial weight loss products.
Effect: Short-term studies have shown that caffeine can increase metabolism by 3-11% and fat burning by 29%.
Efficiency: Some studies have also shown that caffeine may cause moderate weight loss.
Side effects: For some people, caffeine intake can cause anxiety, insomnia, nervousness, and irritability. Caffeine also makes you more dependent and reduces the quality of sleep.
There is no need to take any caffeine-containing pills or supplements. High-quality green tea and coffee are the best choices. They also contain antioxidants and other health benefits.
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Bottom line
Caffeine may increase metabolism and fat burning, but it will only last for a short time. Caffeine can cause tolerance.
4. Orlistat (Ali).
Orlistat is a drug that can be purchased over-the-counter as Alli and prescription drugs under the name Xenical.
What it does: This weight-loss drug can inhibit the digestion of fats, allowing you to consume fewer calories.
Effectiveness A large review of 11 studies shows that orlistat can help you lose 6 pounds (2.7 kg) more than taking fake drugs.
Additional benefits: In a study, orlistat was shown to slightly lower blood pressure and reduce the likelihood of type 2 diabetes by 37%.
Side effects: This drug can cause many side effects, including loose stools, oily stools, flatulence, and uncontrollable bowel movements. It can also lead to a deficiency of fat-soluble vitamins such as vitamins A and D.
To minimize side effects, it is recommended that you follow a low-fat diet.
Interestingly, a low-carbohydrate diet (without any drugs) has proven to be as effective as orlistat or a low-fat diet.
Bottom line
Orlistat (also known as Alli and Xenical) can help you lose weight by reducing the amount of fat you consume. Some side effects are very unpleasant.
5. Raspberry Ketones
Raspberry ketone is a substance found in raspberries that is responsible for its unique smell and is called raspberry ketone.
As a weight loss aid, you can buy a synthetic version of raspberry ketones.
Raspberry ketone was found in the isolated fat cells of rats, which can increase the level of a hormone called adiponectin. This hormone is thought to be related to weight loss.
Effectiveness Although no human studies have used raspberry ketones, a large-scale rat study has shown that they can reduce weight gain.
Side effects These may make your hiccups smell like raspberries
Bottom line
It is not known that raspberry ketones cause weight loss in humans. The rat study that proved its effectiveness was done with large doses.
6. Green coffee bean extract
Coffee beans are just unroasted ordinary coffee beans.
These two substances are believed to help weight loss: caffeine and chlorogenic acid.
What it does: Caffeine may increase fat burning, while chlorogenic acid may slow down the digestion of carbohydrates.
Efficiency: A large number of human studies have shown that green coffee bean extract can help people lose weight.
Supplements helped people lose 5.4 pounds (2.5 kg) more than placebo.
Additional benefits: Green coffee bean extract can lower blood sugar levels and lower blood pressure. It is also rich in antioxidants.
Side effects: It may cause side effects similar to caffeine. It can cause diarrhea and may also be allergic to green coffee beans.
Bottom line
Although green coffee bean extract may cause moderate weight loss in some cases, keep in mind that many of these studies are sponsored by industry.
7. Glucomannan
Glucomannan, also known as konjac, is a type of fiber that can be found in the roots and leaves of elephant yam.
What it does: Glucomannan is absorbed by water and becomes a gel-like substance. It is located in your stomach and promotes satiety. This will help you eat fewer calories.
Effectiveness Within five weeks, glucomannan and a healthy diet can help people lose 3.6 to 4.5 kilograms (or 8-10 pounds) of weight.
Other benefits: Glucomannan is a type of fiber that can be used to feed friendly bacteria in the intestines. As we all know, it can also lower blood sugar, blood cholesterol and triglycerides, and can prevent constipation.
Side effects: This drug can cause bloating and gas, as well as soft stools, and may also interact with oral medications.
Take glucomannan at least 30 minutes before eating and drink a glass of water. Undefined This article provides an objective assessment of glucomannan.
Bottom line
Studies consistently show that fiber glucomannan can be combined with a healthy diet to help people lose weight. It can also improve various health indicators.
8. Meratrim
Meratrim has always been a newcomer to the weight-loss drug market.
It is a combination of two plant extracts that can change the metabolism of fat cells.
Function: It is said to slow down the growth of fat cells, reduce the amount of fat they absorb from the blood, and help burn stored fat.
Efficiency: Only one study was conducted on Meratrim. 100 obese people took Meratrim or placebo and consumed 2000 calories.
Meratrim's team lost 11 lbs (5.2 kg) after 8 weeks and their waist circumference shrank by 4.7 inches (11.9 cm). They have a higher quality of life and lower blood sugar, cholesterol and triglycerides.
Side effects No side effects have been reported.
This article provides a comprehensive review of Meratrim.
Bottom line
Meratrim has been found to cause weight loss and has other health benefits. Industry-sponsored research is not conclusive. More research is needed.
9. Green tea extract
Many weight loss products contain green tea extract.
This is because many studies have shown that EGCG is an effective antioxidant that helps burn fat.
How it works The activity of norepinephrine is believed to be increased by green tea extract, which is a hormone that helps fat burning.
Effectiveness A large number of human studies have shown that green tea extract helps reduce fat and increase fat burning, especially around the stomach.
Side effects: The side effects of green tea extract are generally mild. Some people may experience symptoms if they are sensitive to caffeine.
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Bottom line
Green tea and green tea extract may increase fat burning and help you reduce belly weight.
10. Conjugated Linoleic Acid
Conjugated linoleic acid (or CLA) has been a well-known weight loss supplement for many years.
It is a healthier trans fat that can be found in certain fatty animal foods, such as cheese or butter.
Its role: CLA can reduce appetite, increase metabolism, and stimulate the burning of body fat.
Effectiveness: A major review of 18 studies found that CLA can lose approximately 0.2 pounds (0.1 kg) of body weight per week for up to 6 months.
Another review in 2012 found that CLA can help you lose approximately 3 pounds (1.3 kg) more than placebo pills.
Side effects: The side effects of CLA can have a variety of digestive side effects and may cause long-term damage, including fatty liver, insulin resistance, increased inflammation, and even increased blood sugar.
Bottom line
CLA is an effective weight loss supplement, but it may cause long-term health problems. Even a small amount of weight is not worth losing.
11. Forskolin
Forskolin is an extract of the mint plant, which is said to be very effective for weight loss.
How it works It is thought to increase the level of a compound called cAMP in the cell, which may stimulate fat loss.
Effectiveness A study of 30 obese and overweight men found that forskolin can reduce body fat and increase muscle mass without affecting weight. A second study of 23 overweight women showed no effect.
Side effects There is very limited information on the side effects or safety of this supplement.
Bottom line
Two small studies on forskolin showed conflicting results. Until more research is done, it is best not to take this supplement.
12. Bitter Orange/Synephrine
Bitter orange contains compound synephrine.
Synephrine may be related to ephedrine. This ingredient used to be a common ingredient in many weight-loss drugs.
Due to serious side effects, the US Food and Drug Administration has banned ephedrine as a weight loss ingredient.
What it does: Synephrine and ephedrine have a similar mechanism, but are more effective. It can reduce appetite and increase fat burning.
Effectiveness Although synephrine has not been extensively studied, it has been shown in many studies to cause weight loss.
Side effects: Synephrine can cause serious side effects that affect the heart, similar to ephedrine. It can also make you addicted.
Bottom line
Synephrine is a powerful stimulant and may be effective for weight loss. The side effects can be serious, so be careful.
prescription
There are also many prescription weight loss drugs that have been proven to be effective.
These include Contrave and Phentermine.
A 2014 review found that prescription weight-loss drugs did not work as well as we hoped.
Compared to placebo pills, they can help you lose up to 3-9% of your body weight.
This can only be combined with a healthy weight loss diet. They are not effective by themselves, nor can they provide a solution for obesity.
They may also have side effects.
Take the news home
Here are the 12 clear winners with the strongest evidence:
Weight loss: Glucomannan (CLA), Orlistat [Alli]
not clear
I must warn of the side effects of Orlistat and the negative effect of CLA on metabolism.
This leaves us with green tea extract, glucomannan and caffeine.
These supplements may help, but their impact is minimal at best.
Unfortunately, no weight loss supplement or pill is as effective as a pill.
These may help boost your metabolism and help you lose a few pounds. Unfortunately, this is all it does.
Eating less carbohydrates and more protein is the best way to lose weight. They are more effective than any weight loss drugs.
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